• Diabetes Metab Syndr · Jul 2020

    Vitamin D concentrations and COVID-19 infection in UK Biobank.

    • Claire E Hastie, Daniel F Mackay, Frederick Ho, Carlos A Celis-Morales, Katikireddi Srinivasa Vittal SV Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, G12 8RZ, UK., Claire L Niedzwiedz, Bhautesh D Jani, Paul Welsh, Frances S Mair, Stuart R Gray, Catherine A O'Donnell, Jason Mr Gill, Naveed Sattar, and Jill P Pell.
    • Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, G12 8RZ, UK.
    • Diabetes Metab Syndr. 2020 Jul 1; 14 (4): 561-565.

    Background And AimsCOVID-19 and low levels of vitamin D appear to disproportionately affect black and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D) concentration was associated with COVID-19 risk, and whether it explained the higher incidence of COVID-19 in black and South Asian people.MethodsUK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results. Univariable and multivariable logistic regression analyses were performed for the association between 25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID-19.ResultsComplete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR = 0.99; 95% CI 0.99-0.999; p = 0.013), but not after adjustment for confounders (OR = 1.00; 95% CI = 0.998-1.01; p = 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites OR = 5.32, 95% CI = 3.68-7.70, p-value<0.001; South Asians versus whites OR = 2.65, 95% CI = 1.65-4.25, p-value<0.001). Adjustment for 25(OH)D concentration made little difference to the magnitude of the association.ConclusionsOur findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection.Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.

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