• Hanna Gyllensten, Michael Wiberg, Kristina Alexanderson, Jan Hillert, and Petter Tinghög.
• Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
• BMJ Open. 2016 Nov 17; 6 (11): e012731.

ObjectivesWe compared work disability of patients with multiple sclerosis (MS) from 5 years before with 5 years after diagnosis, with that of matched controls, and analysed whether progression in work disability among patients with MS was associated with sociodemography.DesignPopulation-based cohort study.SettingThe adult Swedish general population.ParticipantsResidents aged 24-57 diagnosed with MS (n=3685) in 2003-2006 and 18 425 matched controls without MS.Primary And Secondary Outcome MeasuresAnnual net days of sickness absence (SA) and disability pension (DP), used as a proxy for work disability, followed from 5 years before to 5 years after diagnosis (ie, T-5-T+5). For patients with MS, regression was used to identify sociodemographic factors related to progression in work disability.ResultsWork disability of patients with MS increased gradually between T-5 and T-1 (mean: 46-82 days) followed by a sharp increase (T+1, 142 days), after which only a marginal increase was observed (T+5, 149 days). The matched controls had less work disability, slightly increasing during the period to a maximum of ∼40 days. Men with MS had a sharper increase in work disability before diagnosis. High educational level was associated with less progression in work disability before and around diagnosis.ConclusionsPatients with MS had more work disability days also 5 years before diagnosis. Several sociodemographic variables were associated with the absolute level and the progression in SA and DP.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

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