• R Löffler, C J Müller, M Peller, H Penzkofer, M Deimling, M Schwaiblmair, J Scheidler, and M Reiser.
• Department of Diagnostic Radiology, Klinikum Grosshadern, University of Munich, Munich, Germany. ralf.loeffler@med.siemens.de
• Magn Reson Med. 2000 Jun 1; 43 (6): 860-6.

AbstractThe behavior of the signal intensity in MRI of human lungs was investigated during inhalation of pure oxygen. Nine volunteers were examined, five using a breath-hold and four using a non-breath-hold technique. Four coronal slices were acquired in each volunteer using an inversion recovery turbo spin-echo sequence. The inversion time of the sequence was optimized for maximum contrast. Breathing of pure oxygen and room air was alternated in the volunteers. Breath-hold and non-breath-hold cases were compared. Breathing pure oxygen lead to a statistically significant signal intensity increase (up to 18%) compared to breathing room air. In addition, T(1) maps were acquired during breathing 100% oxygen and room air. Inhalation of pure oxygen reduced the mean T(1) time of the lungs from 1280 (+/-85) msec to 1224 (+/-139) msec without breath-hold and from 1219 (+/-176) to 1074 (+/-92) msec with breath-hold. Therefore, an optimized sequence and measurement protocol provided significant signal intensity changes utilizing 100% oxygen. Magn Reson Med 43:860-866, 2000.Copyright 2000 Wiley-Liss, Inc.

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