• Int. J. Antimicrob. Agents · Aug 2020

    Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein.

    • Naveen Vankadari.
    • Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia. Electronic address: Naveen.vankadari@monash.edu.
    • Int. J. Antimicrob. Agents. 2020 Aug 1; 56 (2): 105998.

    AbstractThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.Copyright © 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

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