• Fabrizio Sallustio, Giacomo Koch, Silvia Di Legge, Costanza Rossi, Barbara Rizzato, Simone Napolitano, Domenico Samà, Natale Arnò, Angela Giordano, Domenicantonio Tropepi, Giulia Misaggi, Marina Diomedi, Costantino Del Giudice, Alessio Spinelli, Sebastiano Fabiano, Matteo Stefanini, Daniel Konda, Carlo Andrea Reale, Enrico Pampana, Giovanni Simonetti, Paolo Stanzione, and Roberto Gandini.
• Stroke Unit, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy; Fondazione Santa Lucia IRCCS, Rome, Italy. Electronic address: fabriziosallustio@libero.it.
• J Stroke Cerebrovasc Dis. 2013 Nov 1; 22 (8): e323-31.

BackgroundSeverely impaired patients with persisting intracranial occlusion despite standard treatment with intravenous (IV) administration of recombinant tissue plasminogen activator (rtPA) or presenting beyond the therapeutic window for IV rtPA may be candidates for interventional neurothrombectomy (NT). The safety and efficacy of NT by the Penumbra System (PS) were compared with standard IV rtPA treatment in patients with severe acute ischemic stroke (AIS) caused by large intracranial vessel occlusion in the anterior circulation.MethodsConsecutive AIS patients underwent a predefined treatment algorithm based on arrival time, stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score, and site of arterial occlusion on computed tomographic angiography (CTA). NT was performed either after a standard dose of IV rtPA (bridging therapy [BT]) or as single treatment (stand-alone NT [SAT]). Rates of recanalization, symptomatic intracranial bleeding (SIB), mortality, and functional outcome in NT patients were compared with a historical cohort of IV rtPA treated patients (i.e., controls). Three-month favourable outcome was defined as a modified Rankin Scale (mRS) score ≤2.ResultsForty-six AIS patients were treated with NT and 51 with IV rtPA. The 2 groups did not differ with regard to demographics, onset NIHSS score (18.5±4 v 17±5; P=.06), or site of intracranial occlusion. Onset-to-treatment time in the NT and IV rtPA groups was 230 minutes (±78) and 176.5 (±44) minutes, respectively (P=.001). NT patients had significantly higher percentages of major improvement (≥8 points NIHSS score change at 24 hours; 26% v 10%; P=.03) and partial/complete recanalization (93.5% v 45%; P<.0001) compared to controls. Treatment by either SAT or BT similarly improved the chance of early recanalization and early clinical improvement. No significant differences were observed in the rate of SIB (11% v 6%), 3-month mortality (24% v 25%), or favorable outcome (40% v 35%) between NT and IV rtPA patients.ConclusionsDespite significantly delayed time of intervention, NT patients had higher rates of recanalization and early major improvement, with no differences in symptomatic intracranial hemorrhages. Early NIHSS score improvement did not translate into better 3-month mortality or outcome. NT seems a safe and effective adjuvant treatment strategy for selected patients with severe AIS secondary to large intracranial vessel occlusion in the anterior circulation.Copyright © 2013 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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