• Mia J Biondi, Alex Marchand-Austin, Kirby Cronin, Natasha Nanwa, Vithusha Ravirajan, Erin Mandel, Lee W Goneau, Tony Mazzulli, Hemant Shah, Camelia Capraru, Janssen Harry L A HLA Viral Hepatitis Care Network Study Group/Toronto Centre for Liver Disease (Biondi, Mandel, Shah, Capraru, Janssen, Feld), University Health Network,, Beate Sander, and Jordan J Feld.
• Viral Hepatitis Care Network Study Group/Toronto Centre for Liver Disease (Biondi, Mandel, Shah, Capraru, Janssen, Feld), University Health Network, Toronto, Ont.; Arthur Labatt Family School of Nursing (Biondi), Western University, London, Ont.; Public Health Ontario Laboratory (Marchand-Austin, Cronin, Ravirajan, Goneau, Mazzulli), Toronto, Ont.; National Microbiology Laboratory (Cronin), Public Health Agency of Canada, Winnipeg, Man.; Public Health Ontario (Nanwa, Ravirajan, Sander); ICES Central (Nanwa, Sander); Sinai Health System/University Health Network (Mazzulli); Institute of Medical Sciences (Feld), University of Toronto, Toronto, Ont.
• CMAJ. 2020 Oct 26; 192 (43): E1299-E1305.

BackgroundOntario is 1 of 5 provinces that immunize adolescents for hepatitis B virus (HBV), despite the World Health Organization recommendation for universal birth dose vaccination. One rationale for not vaccinating at birth is that universal prenatal screening and related interventions prevent vertical transmission. The aims of our study were to evaluate the uptake and epidemiology of prenatal HBV screening, and to determine the number of children in Ontario with a diagnosis of HBV before adolescent vaccination.MethodsWe extracted data from ICES, Public Health Ontario and Better Outcomes & Registry Network (BORN) Ontario databases. We assessed prenatal screening uptake and prevalence of prenatal hepatitis B surface antigen (HBsAg) from 2012 to 2016, as well as subsequent hepatitis B e-antigen (HBeAg) and HBV DNA testing and percent positivity. We used age and region to subcategorize the results. In a separate unlinked analysis, we evaluated the number of children positive for HBV aged 0-11 years who were born in Ontario from 2003 to 2013.ResultsFrom 2012 to 2016, 93% of pregnant women were screened for HBV, with an HBsAg prevalence of 0.6%. Prevalence of HBsAg increased with age, peaking at older than 45 years at 3%. North Toronto had the highest overall prevalence of 1.5%, whereas northern Ontario had the lowest. Of women who were HBsAg positive, HBeAg and HBV DNA tests were subsequently ordered in 13% and 38%, respectively. Of children born in Ontario between 2003 and 2013, 139 of 23 759 tested positive for HBV.InterpretationPrenatal HBV screening is not universal and subsequent evaluation is poor, limiting optimal intervention and possibly contributing to some Ontario-born children being given a diagnosis of HBV before age 12 years. These findings underscore the limitations of the province's adolescent vaccination strategy.© 2020 Joule Inc. or its licensors.

30 keywords...

hide…