• Neurosurgery · Jan 2021

    Review

    Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.

    • Harish N Vasudevan, Calixto-Hope G Lucas, Javier E Villanueva-Meyer, Philip V Theodosopoulos, and David R Raleigh.
    • Department of Radiation Oncology, University of California, San Francisco, San Francisco, California.
    • Neurosurgery. 2021 Jan 13; 88 (2): 234-245.

    AbstractIn this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages.Published by Oxford University Press on behalf of Congress of Neurological Surgeons 2020.

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