• Krisztina L Malisza, Cheryl Jones, Marco L H Gruwel, Derek Foreman, Paul Fernyhough, and Nigel A Calcutt.
• National Research Council, Institute for Biodiagnostics, Winnipeg, MB, Canada. Kris.malisza@nrc-cnrc.gc.ca
• J Magn Reson Imaging. 2009 Aug 1; 30 (2): 271-6.

PurposeTo determine if differences exist between control and diabetic rats in functional magnetic resonance imaging (fMRI) activity of the spinal cord and if fMRI can provide a means of early detection of diabetic neuropathy.Materials And MethodsfMRI of the spinal cord, using noxious electrical stimulation (15 V ( approximately 8 mA), 0.3 msec, 3 Hz) of the hind paw, was performed in groups of control and streptozotocin (STZ)-induced type 1 diabetic rats.ResultsDiabetic rats were lighter, hyperglycemic, and had lower blood pH than controls. fMRI activity at the lumbar enlargement of the spinal cord was identified in the dorsal horn ipsilateral to stimulus of all animals. Signal intensity changes across the lumbar spinal cord during periods of activity were not significantly different between control and diabetic rats, with a trend toward greater signal changes in controls. When specific regions of the spinal cord were analyzed, control rats exhibited significantly increased blood-oxygen level-dependent (BOLD) fMRI activity in both ipsilateral and contralateral dorsal horn compared to diabetic rats.ConclusionThe results of this study are consistent with reports that primary afferent input to the spinal cord is diminished by diabetes, and suggest that BOLD fMRI may be useful in early detection of diabetic neuropathy.(c) 2009 Wiley-Liss, Inc.

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