• Nahoko Kaniwa, Yoshiro Saito, Michiko Aihara, Kayoko Matsunaga, Masahiro Tohkin, Kouichi Kurose, Jun-ichi Sawada, Hirokazu Furuya, Yukitoshi Takahashi, Masaaki Muramatsu, Shigeru Kinoshita, Masamichi Abe, Hiroko Ikeda, Mariko Kashiwagi, Yixuan Song, Mayumi Ueta, Chie Sotozono, Zenro Ikezawa, Ryuichi Hasegawa, and JSAR research group.
• Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo. nkaniwa@nihs.go.jp
• Pharmacogenomics. 2008 Nov 1; 9 (11): 1617-22.

IntroductionStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 and HLA-B*5801 with carbamazepine- and allopurinol-induced severe cutaneous adverse reactions were found in Han Chinese patients, respectively, but ethnic differences in the associations have been reported. The objective of this study is to clarify the involvement of HLA-B*1502 and HLA-B*5801 in Japanese SJS/TEN patients.MethodsHLA-B genotyping was performed on 58 Japanese SJS/TEN patients between July 2006 and April 2008 from multicenters in Japan.ResultsThere were no HLA-B*1502 carriers among 58 SJS/TEN patients. This patient group included seven carbamazepine-related and 11 aromatic anti-epileptic agent-related SJS/TEN patients. In addition, there were five HLA-B*5801 carriers, which included four allopurinol-related SJS/TEN patients.ConclusionWhile HLA-B*1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN, HLA-B*5801 was significantly associated with allopurinol-related SJS/TEN in Japanese.

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