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Curr Pain Headache Rep · Oct 2015
ReviewMedical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence.
- Bjorn Jensen, Jeffrey Chen, Tim Furnish, and Mark Wallace.
- Center for Pain Medicine, University of California San Diego, 9300 Campus Point Drive, Mail Code 7651, La Jolla, CA, 92037, USA, bbjensen@ucsd.edu.
- Curr Pain Headache Rep. 2015 Oct 1; 19 (10): 50.
AbstractCannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions.
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