• Sichuan Da Xue Xue Bao Yi Xue Ban · Jan 2013

    [Inflammatory factors promote the expression of PD-L1 in Tca8113].

    • Li-Bing Lu, Jiao Chen, Yun Feng, Chen-Chen Zhou, and Ping Zhang.
    • State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
    • Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Jan 1; 44 (1): 42-5.

    ObjectiveTo investigate the mechanism of immunologic escape in the tumor microenvironment, study the expression of programmed death 1 ligand-1 (PD-L1) in Tca8113 with treatment of inflammatory factors.MethodsThe expression of PD-L1 treated with inflammatory factors (IL-1beta, IL-2, IL-6, TNF-alpha, IFN-gamma) was detected by flow cytometry (FCM).ResultsThe expression of PD-L1 in Tca8113 was up-regulated conspicuously with treatment of inflammatory factors (P < 0.05), including: IL-1beta, IL-6, TNF-alpha, IFN-y. And the factors played the role in synergistic effects, most significantly in the groups of IL-1beta + IFN-gamma, TNF-alpha + IFN-gamma and IL-1beta + IL-6 + IFN-gamma + TNF-alpha. But the influence of IL-2 on the expression of PD-L1 was not significant (P > 0.05).ConclusionWith the up-regulated expression of PD-L1, the tumor would be escaped more easily from the immunoreactions, while there were an abundance of inflammatory factors in the tumor microenvironment.

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