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Cell. Physiol. Biochem. · Jan 2018
Choline Inhibits Ischemia-Reperfusion-Induced Cardiomyocyte Autophagy in Rat Myocardium by Activating Akt/mTOR Signaling.
- Pengzhou Hang, Jing Zhao, Zhenli Su, Hanqi Sun, Tingting Chen, Lihui Zhao, and Zhimin Du.
- Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University (Institute of Clinical Pharmacy, the Heilongjiang Key Laboratory of Drug Research, Harbin Medical University), Harbin, China.
- Cell. Physiol. Biochem. 2018 Jan 1; 45 (5): 2136-2144.
AbstractBackgroud/Aims: Growing evidence suggests that both cardiomyocyte apoptosis and excessive autophagy exacerbates cardiac dysfunction during myocardial ischemia-reperfusion (IR). As a precursor of acetylcholine, choline has been found to protect the heart by repressing ischemic cardiomyocyte apoptosis. However, the relationship between choline and cardiomyocyte autophagy is unclear. The present study aimed to investigate whether autophagy was involved in the cardioprotection of choline during IR.© 2018 The Author(s). Published by S. Karger AG, Basel.
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