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Int. J. Tuberc. Lung Dis. · Oct 2011
Comparative StudyUse of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease.
- C-C Shu, L-N Lee, M-F Wu, C-H Lee, J-T Wang, J-Y Wang, C-J Yu, and TAMI Group.
- Department of Internal Medicine, National Taiwan University Hospital, Taipei.
- Int. J. Tuberc. Lung Dis. 2011 Oct 1; 15 (10): 1415-20.
BackgroundSerum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD).ObjectiveTo investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD.DesignFrom April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma.ResultsOf the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age >65 years and higher serum sTREM-1 level were associated with worse 6-month survival.ConclusionIn patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.
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