• J. Thromb. Haemost. · Jul 2019

    Multicenter Study Observational Study

    Drug levels and bleeding complications in atrial fibrillation patients treated with direct oral anticoagulants.

    • Sophie Testa, Cristina Legnani, Emilia Antonucci, Oriana Paoletti, Claudia Dellanoce, Benilde Cosmi, Vittorio Pengo, Daniela Poli, Rossella Morandini, Roberto Testa, Armando Tripodi, Gualtiero Palareti, and Coordinator of START2-Register.
    • Haemostasis and Thrombosis Center, Ospedale di Cremona, Cremona, Italy.
    • J. Thromb. Haemost. 2019 Jul 1; 17 (7): 1064-1072.

    AbstractEssentials Currently, DOACs are given at fixed doses and do not require laboratory monitoring. Direct oral anticoagulant-specific measurements were performed at trough and peak. Patients who developed bleeding events showed higher DOAC plasma levels at peak. This study suggests the need of a more accurate DOAC dose assessment.© 2019 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

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