• Thrombosis research · Sep 2020

    Review

    Mechanisms involved in the development of thrombocytopenia in patients with COVID-19.

    • Yujiao Zhang, Xiaoyuan Zeng, Yingying Jiao, Zongpeng Li, Qifa Liu, Jieyu Ye, and Mo Yang.
    • Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    • Thromb. Res. 2020 Sep 1; 193: 110-115.

    AbstractCorona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia and thrombocytopenia are not rare in COVID-19 patients, and a smaller population of these patients had leukopenia. Thrombocytopenia was detected in 5-41.7% of the patients with COVID-19. Analyzing the dynamic decrease in platelet counts may be useful in the prognosis of patients with COVID-19. However, the mechanisms underlying the development of thrombocytopenia remain to be elucidated. This review summarizes the hematological changes in patients infected with SARS-CoV-2 and possible underlying mechanisms of thrombocytopenia development.Copyright © 2020. Published by Elsevier Ltd.

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