• The FEBS journal · Sep 2020

    Review

    A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2.

    • Cassandra L Atzrodt, Insha Maknojia, Robert D P McCarthy, Tiara M Oldfield, Jonathan Po, Kenny T L Ta, Hannah E Stepp, and Thomas P Clements.
    • Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
    • FEBS J. 2020 Sep 1; 287 (17): 3633-3650.

    AbstractThe emergence of the SARS-CoV-2 strain of the human coronavirus has thrown the world into the midst of a new pandemic. In the human body, the virus causes COVID-19, a disease characterized by shortness of breath, fever, and pneumonia, which can be fatal in vulnerable individuals. SARS-CoV-2 has characteristics of past human coronaviruses, with close genomic similarities to SARS-CoV, the virus that causes the disease SARS. Like these related coronaviruses, SARS-CoV-2 is transmitted through the inhalation of droplets and interaction with contaminated surfaces. Across the world, laboratories are developing candidate vaccines for the virus - with vaccine trials underway in the United States and the United Kingdom - and considering various drugs for possible treatments and prophylaxis. Here, we provide an overview of SARS-CoV-2 by analyzing its virology, epidemiology, and modes of transmission while examining the current progress of testing procedures and possible treatments through drugs and vaccines.© 2020 Federation of European Biochemical Societies.

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