• Wenjie Yang, Qiqi Cao, Le Qin, Xiaoyang Wang, Zenghui Cheng, Ashan Pan, Jianyi Dai, Qingfeng Sun, Fengquan Zhao, Jieming Qu, and Fuhua Yan.
• Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai 200025, China.
• J. Infect. 2020 Apr 1; 80 (4): 388-393.

BackgroundLittle is known about COVID-19 outside Hubei. The aim of this paper was to describe the clinical characteristics and imaging manifestations of hospitalized patients with confirmed COVID-19 infection in Wenzhou, Zhejiang, China.MethodsIn this retrospective cohort study, 149 RT-PCR confirmed positive patients were consecutively enrolled from January 17th to February 10th, 2020 in three tertiary hospitals of Wenzhou. Outcomes were followed up until Feb 15th, 2020.FindingsA total of 85 patients had Hubei travel/residence history, while another 49 had contact with people from Hubei and 15 had no traceable exposure history to Hubei. Fever, cough and expectoration were the most common symptoms, 14 patients had decreased oxygen saturation, 33 had leukopenia, 53 had lymphopenia, and 82 had elevated C-reactive protein. On chest computed tomography (CT), lung segments 6 and 10 were mostly involved. A total of 287 segments presented ground glass opacity, 637 presented mixed opacity and 170 presented consolidation. Lesions were more localized in the peripheral lung with a patchy form. No significant difference was found between patients with or without Hubei exposure history. Seventeen patients had normal CT on admission of these, 12 had negative findings even10 days later.InterpretationMost patients presented with a mild infection in our study. The imaging pattern of multifocal peripheral ground glass or mixed opacity with predominance in the lower lung is highly suspicious of COVID-19 in the first week of disease onset. Nevetheless, some patients can present with a normal chest finding despite testing positive for COVID-19.FundingWe did not receive any fundings.Copyright © 2020. Published by Elsevier Ltd.

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