• Zihao Wan, Chien-Wei Lee, Shuai Yuan, and Oscar Kuang-Shen Lee.
• MD. Doctoral Student, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
• Sao Paulo Med J. 2020 Sep 1; 138 (5): 393399393-399.

BackgroundTumor protein p63 (p63) has been reported to be highly expressed in giant cell tumor of bone (GCTB). Whether p63 can be treated as a diagnostic marker for GCTB remains unclear.ObjectiveWe conducted a meta-analysis to evaluate the applicability of p63 in diagnosing GCTB.Design And SettingSystematic review and meta-analysis carried out in a public hospital, Hong Kong, China.MethodsWe searched PubMed, EMBASE and the Cochrane Library from inception to April 30, 2019. Literature in English or Chinese about the differential diagnosis of GCTB using p63 were included. -Animal experiments, reviews, correspondence, case reports, expert opinions and editorials were excluded. Studies were also excluded if they did not provide sufficient information to construct a 2 × 2 contingency table. We calculated individual and pooled sensitivities and specificities. We used I² as an indicator of heterogeneity.ResultsOut of 88 records identified, 8 articles on 788 GCTB patients fulfilled the inclusion criteria and were included in the present analysis. Bivariate analyses yielded a pooled mean sensitivity of 0.87 (95% confidence interval, CI, 0.72-0.95) and specificity of 0.71 (95% CI, 0.56-0.82) for using p63 as a biomarker in diagnosing GCTB. The area under the receiver operating characteristic curve was 0.86 (95% CI, 0.82-0.88).Conclusionp63 is a helpful indicator in diagnosing GCTB due to its high sensitivity and specificity. -Nonetheless, the results need to be carefully interpreted based on other diagnostic methods such as imaging.Systematic Review Registration164115 (PROSPERO registration number).

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