• Keilla Martins Milby, Alvaro Nagib Atallah, César Ramos Rocha-Filho, PintoAna Carolina Pereira NunesACPN0000-0002-1505-877XMSc. Physiotherapist and Doctoral Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil; Professor, Biological and Health Sciences Department, Univ, RochaAline Pereira daAPD0000-0002-0863-6500MSc. Pharmacist and Doctoral Student, Evidence-Based Health Program, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil; Volunteer Researcher, Cochrane Brazil, São Paulo (SP), Brazil., Felipe Sebastião de Assis Reis, Nelson Carvas Junior, Vinicius Tassoni Civile, Rodolfo Rodrigo Pereira Santos, Laura Jantsch Ferla, Giulia Fernandes Moça Trevisani, Gabriel Sodré Ramalho, Maria Eduarda Dos Santos Puga, and TrevisaniVirgínia Fernandes MoçaVFM0000-0002-7180-6285MD, MSc, PhD. Rheumatologist, Discipline of Emergency and Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil; Rheumatologist.
• PhD. Nurse, Volunteer Researcher at Cochrane Brazil, São Paulo (SP), Brazil.
• Sao Paulo Med J. 2020 Nov 1; 138 (6): 498504498-504.

BackgroundThe numbers of cases of arboviral diseases have increased in tropical and subtropical regions while the coronavirus disease (COVID-19) pandemic overwhelms healthcare systems worldwide. The clinical manifestations of arboviral diseases, especially dengue fever, can be very similar to COVID-19, and misdiagnoses are still a reality. In the meantime, outcomes for patients and healthcare systems in situations of possible syndemic have not yet been clarified.ObjectiveWe set out to conduct a systematic review to understand and summarize the evidence relating to clinical manifestations, disease severity and prognoses among patients coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and arboviruses.MethodsWe conducted a rapid systematic review with meta-analysis, on prospective and retrospective cohorts, case-control studies and case series of patients with confirmed diagnoses of SARS-CoV-2 and arboviral infection. We followed the Cochrane Handbook recommendations. We searched EMBASE, MEDLINE, Cochrane Library, LILACS, Scopus and Web of Science to identify published, ongoing and unpublished studies. We planned to extract data and assess the risk of bias and the certainty of evidence of the studies included, using the Quality in Prognosis Studies tool and the Grading of Recommendations Assessment.ResultsWe were able to retrieve 2,407 citations using the search strategy, but none of the studies fulfilled the inclusion criteria.ConclusionThe clinical presentations, disease severity and prognoses of patients coinfected with SARS-CoV-2 and arboviruses remain unclear. Further prospective studies are necessary in order to provide useful information for clinical decision-making processes.Protocol Registration Number In The Prospero DatabaseCRD42020183460.

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