• Seminars in nephrology · Nov 2012

    Review

    High-output heart failure: how to define it, when to treat it, and how to treat it.

    • Haimanot Wasse and M Salman Singapuri.
    • Division of Nephrology, Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. hwasse@emory.edu
    • Semin. Nephrol. 2012 Nov 1; 32 (6): 551-7.

    AbstractAlthough hemodialysis patients who initiate and maintain a permanent form of dialysis vascular access have improved all-cause and cardiovascular survival compared with those who use catheters, the presence of an arteriovenous fistula has been shown to have a short-term, adverse effect on cardiac function. Through its effect as a left-to-right extracardiac shunt, the arteriovenous fistula can increase cardiac workload substantially, and, in certain patients, result in a high-output state and resultant heart failure over time. Here we review the mechanisms by which dialysis arteriovenous access may promote the development of high-output cardiac failure in end-stage renal disease patients, describe risk factors for and the diagnosis of high-output heart failure, and suggest management strategies for patients who develop high-output heart failure.Copyright © 2012 Elsevier Inc. All rights reserved.

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