• Wolfgang Schillinger, Mark Hünlich, Stephan Baldus, Taoufik Ouarrak, Peter Boekstegers, Ulrich Hink, Christian Butter, Raffi Bekeredjian, Björn Plicht, Horst Sievert, Joachim Schofer, Jochen Senges, Thomas Meinertz, and Gerd Hasenfuß.
• Herzzentrum Göttingen, Abt. Kardiologie und Pneumologie, Universitätsmedizin Göttingen, Göttingen, Germany. schiwolf@med.uni-goettingen.de
• EuroIntervention. 2013 May 20; 9 (1): 84-90.

AimsThe influence of age on baseline demographics and outcomes of patients selected for MitraClip has not been previously investigated.Methods And ResultsBaseline demographics and acute outcomes in 1,064 patients from the German TRAMI registry were stratified by age (525 patients ≥76 years and 539 patients <76 years). In elderly patients, logistic EuroSCORE was higher (25[15-40]% vs. 18[10-31]%, p<0.0001) and the proportion of women was greater (47.2% vs. 29.3%, p<0.0001). Elderly patients were more likely to have preserved left ventricular ejection fraction >50% (40.1% vs. 21.8%, p<0.0001) and degenerative mitral regurgitation (DMR, 35.3% vs. 25.6%, p<0.01). Age was the most frequent reason for non-surgical treatment in the elderly (69.4% vs. 36.1%, p<0.0001). The intrahospital MACCE (death, myocardial infarction, stroke) was low in both groups (3.5% vs. 3.4%, p=0.93) and the proportion of non-severe mitral regurgitation at discharge was similar (95.8% vs. 96.4%, p=0.73). A logistic regression model did not reveal any significant impact of age on acute efficacy and safety of MitraClip therapy. In both groups, the majority of patients were discharged home (81.8% vs. 86.2%, p=0.06).ConclusionsElderly and younger patients have similar benefits from MitraClip therapy. Age was the most frequent cause for denying surgery in elderly patients.

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