• Clin Epidemiol Glob Health · Aug 2020

    Review

    Remdesivir and its antiviral activity against COVID-19: A systematic review.

    • Andri Frediansyah, Firzan Nainu, Kuldeep Dhama, Mudatsir Mudatsir, and Harapan Harapan.
    • Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia.
    • Clin Epidemiol Glob Health. 2020 Aug 7.

    BackgroundThe aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.MethodsAvailable publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.ResultsRemdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients.ConclusionAlthough remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.© 2020 INDIACLEN. Published by Elsevier, a division of RELX India, Pvt. Ltd.

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