• J. Cardiothorac. Vasc. Anesth. · Aug 2000

    Plasma-soluble E-selectin after cardiopulmonary bypass in children: is it a marker of the postoperative course?

    • G Paret, T Prince, N Keller, O Dagan, Y Sasson, A Barzilai, D Guthmann, and Z Barzilay.
    • Department of Pediatric Intensive Care, Chaim Sheba Medical Center, Tel Hashomer, Israel.
    • J. Cardiothorac. Vasc. Anesth. 2000 Aug 1; 14 (4): 433-7.

    ObjectiveTo investigate the relationship and possible role of soluble adhesion molecule E-selectin in the postoperative course in children undergoing cardiopulmonary bypass (CPB).DesignProspective cohort study.SettingPediatric intensive care unit of a university hospital.ParticipantsThirteen children who were candidates for cardiac surgery.InterventionsNone.Measurements And Main ResultsSerial blood samples of 13 CPB patients were collected from the arterial catheter or from the bypass circuits preoperatively; on initiation of CPB; on termination of CPB; and 1, 2, 4, 8, 12, 18, 24, and 48 hours postoperatively. Plasma was recovered immediately, aliquoted, and frozen at -70 degrees C until use. Circulating soluble selectin molecules were measured with a sandwich enzyme-linked immunosorbent assay technique. There were significant changes in plasma levels of soluble E-selectins in patients after CPB, and these levels were associated with patient characteristics, operative variables, and postoperative course. Soluble E-selectin correlated significantly with inotropic support and the use of anti-inflammatory drugs. There was a significant association between the development of postoperative sepsis and soluble E-selectin levels. No correlation was found between soluble E-selectins and duration of CPB, aortic cross-clamping, or hemodynamic variables, including heart rate and mean systemic arterial pressure.ConclusionThese results suggest a relationship between CPB-induced mediators and early and late clinical effects. Although the mechanism for the increase of soluble E-selectin remains to be elucidated, the upregulation of soluble E-selectin indicates neutrophil activation, and its inhibition may represent a target for reducing the inflammatory response associated with CPB.

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