• Korean J Ophthalmol · Mar 2009

    Case Reports

    Topical and oral voriconazole in the treatment of fungal keratitis.

    • Sang Joon Lee, Jung Joo Lee, and Shin Dong Kim.
    • Department of Ophthalmology, College of Medicine, Kosin University, Busan, Korea.
    • Korean J Ophthalmol. 2009 Mar 1; 23 (1): 46-8.

    AbstractWe describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.

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