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- H Nagabushan and H S Roopadevi.
- Department of Pharmacology, Mandya Institute of Medical Sciences, Mandya, Karnataka, India.
- J Postgrad Med. 2014 Jul 1; 60 (3): 300-2.
AbstractMultidrug-resistant and extensively drug-resistant tuberculosis (TB) are emerging global health threats. Bedaquiline is a new antituberculous drug belonging to the diarylquinoline class that efficiently inhibits the adenosine triphosphate synthase enzyme of Mycobacterium tuberculosis. It is a bactericidal and long-acting drug. It inhibits both dormant as well as replicating bacterial sub-populations and thus shortens the duration of TB treatment. This drug has been approved by the Food and Drug Administration in December 2012 for the management of multidrug resistant-TB. The drug marks the introduction of a new addition to the TB armamentarium after four decades.
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