• J. Matern. Fetal. Neonatal. Med. · Jan 2015

    Evaluation of the ability of cervical length and fetal fibronectin measurement to predict preterm delivery in asymptomatic women with risk factors.

    • Mei-Xi Zhou, Jing Zhou, Ying Bao, Yun-Qin Chen, and Chang Cai.
    • Department of Gynecology and Obstetrics, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , People's Republic of China.
    • J. Matern. Fetal. Neonatal. Med. 2015 Jan 1; 28 (2): 153-7.

    ObjectiveTo evaluate the power of transvaginal ultrasound cervical length (CL) and fetal fibronectin (fFN) measurement for the prediction of preterm delivery (PTD) in asymptomatic women with risk factors.MethodsBetween January 2010 and October 2012, 218 women with singleton pregnancies and a high risk for PTD (i.e. prior history of PTD, cervical surgeries, late miscarriages, uterine abnormalities or premature rupture of the membranes) were selected. CL was measured by transvaginal ultrasonography between 14 and 22 weeks, and a CL<2.5 cm was considered to be short. The fFN was measured with a sterile speculum examination. The primary outcome was the spontaneous PTD rate at <34(+0) and <37(+0) weeks, and the PTD rate was analyzed by either of two methods alone or combined.ResultsThere were 213 cases included in the analysis, and 47 women (22.1%) had positive fFN. The average CL of women with positive fFN (2.3 ± 0.9 cm) was significantly shorter than that of women with negative fFN (3.1 ± 0.8 cm; p=0.02). There were 25 (11.7%) and 38 (18.8%) cases with PTD at <34(+0) and <37(+0) weeks, respectively. By individual analyses, the highest PTD rate was 51.2% in women with positive fFN at <37(+0) weeks. The sensitivity and diagnostic efficiency values for PTD prediction by CL were low at <34(+0) and <37(+0) weeks. The values of diagnostic efficiency by fFN were >80% at <34(+0) and <37(+0) weeks. In the combined analysis, the highest PTD rate was 57.1% in women with CL ≤ 2.5 cm and positive fFN at <37(+0) weeks. The Kaplan-Meier curve indicated that there were significant differences among the four groups (χ(2)=54.261; p=0.000).ConclusionsThese results indicate a significant correlation between fFN and PTD prediction. The PTD prediction could be enhanced by combined CL and fFN measurement.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…