• Trends in immunology · Jan 2012

    Review

    Participation of blood vessel cells in human adaptive immune responses.

    • Jordan S Pober and George Tellides.
    • Yale University School of Medicine, PO Box 208089, 10 Amistad Street, RM 401, New Haven, CT 06520-8089, USA. jordan.pober@yale.edu
    • Trends Immunol. 2012 Jan 1; 33 (1): 49-57.

    AbstractCirculating T cells contact blood vessels either when they extravasate across the walls of microvessels into inflamed tissues or when they enter into the walls of larger vessels in inflammatory diseases such as atherosclerosis. The blood vessel wall is largely composed of three cell types: endothelial cells lining the entire vascular tree; pericytes supporting the endothelium of microvessels; and smooth muscle cells forming the bulk of large vessel walls. Each of these cell types interacts with and alters the behavior of infiltrating T cells in different ways, making these cells active participants in the processes of immune-mediated inflammation. In this review, we compare and contrast what is known about the nature of these interactions in humans.Copyright © 2011 Elsevier Ltd. All rights reserved.

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