• Paul G Mulquiney, Kate E Hoy, Zafiris J Daskalakis, and Paul B Fitzgerald.
• Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Department of Psychological Medicine, Commercial Rd., Melbourne, Victoria 3004, Australia.
• Clin Neurophysiol. 2011 Dec 1; 122 (12): 2384-9.

ObjectiveThe aim of this study was to determine if working memory (WM) performance is significantly improved after the delivery of transcranial random noise stimulation (tRNS) to the left dorsolateral prefrontal cortex (DLPFC), compared to an active comparator or sham.MethodsTen participants undertook three experimental sessions in which they received 10 min of anodal tDCS (active comparator), tRNS or sham tDCS whilst performing the Sternberg WM task. Intra-stimulation engagement in a WM task was undertaken as this has been previously shown to enhance the effects of tDCS. Experimental sessions were separated by a minimum of 1 week. Immediately prior to and after each stimulation session the participants were measured on speed and accuracy of performance on an n-back task.ResultsThere was significant improvement in speed of performance following anodal tDCS on the 2-back WM task; this was the only significant finding.ConclusionsThe results do not provide support for the hypothesis that tRNS improves WM. However, the study does provide confirmation of previous findings that anodal tDCS enhances some aspects of DLPFC functioning. Methodological limitations that may have contributed to the lack of significant findings following tRNS are discussed.SignificanceAnodal tDCS may have significant implications for WM remediation in psychiatric conditions, particularly schizophrenia.Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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