• Curr Opin Pulm Med · Sep 2017

    Review

    Antifibrotic drugs as treatment of nonidiopathic pulmonary fibrosis interstitial pneumonias: the time is now (?).

    • Michael Kreuter, Julia Wälscher, and Jürgen Behr.
    • aCenter for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg bMember of the German Center for Lung Research cDepartment of Internal Medicine V, Comprehensive Pneumology Center, Asklepios Fachkliniken, University of Munich, Munich, Bavaria, Germany.
    • Curr Opin Pulm Med. 2017 Sep 1; 23 (5): 418-425.

    Purpose Of ReviewTherapeutic advances in the management of idiopathic pulmonary fibrosis (IPF) has led to improved outcomes with the use of the antifibrotic agents pirfenidone and nintedanib, with a number of randomized studies demonstrating benefits in slowing disease progression in IPF. However, treatment of other fibrosing interstitial lung diseases (ILD) remains challenging.Recent FindingsObservational and uncontrolled studies investigating pirfenidone and nintedanib in non-IPF ILDs suggest potential benefits, although the data is weak. A number of randomized controlled trials evaluating pirfenidone and nintedanib in a variety of fibrosing ILDs are currently enrolling or planned.SummaryThe review will discuss the rationale for use of established antifibrotic drugs approved for IPF for use in non-IPF ILD, describe supportive data from observational studies and ongoing clinical trials.

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