• James S Krause, Yue Cao, and Clark Jillian M R JMR College of Health Professions, Medical University of South Carolina, Charleston, SC..
• College of Health Professions, Medical University of South Carolina, Charleston, SC. Electronic address: krause@musc.edu.
• Arch Phys Med Rehabil. 2017 Dec 1; 98 (12): 2464-2470.

ObjectiveTo identify the association of pain intensity, pain interference, and pain medication use with risk of mortality after spinal cord injury, controlling for demographic, injury, socioeconomic, and health factors.DesignProspective cohort study.SettingAcademic medical center.ParticipantsAll participants (N=2535) had traumatic spinal cord injury of at least 1-year duration at enrollment, with noncomplete recovery (American Spinal Injury Association Impairment Scale grades A-D). Mortality status was obtained for 2535 individuals, and 335 were deceased as of 2014.InterventionsNot applicable.Main Outcome MeasuresMortality status as of December 31, 2014, identified by the National Death Index.ResultsPreliminary bivariate analyses indicated that deceased participants were more likely to be older at injury, have more years postinjury, be men, and have a severe injury, low income, less education, and poorer health indicators. The final Cox model indicated that those who used pain medication daily were 51% more likely to be deceased at follow-up (hazard ratio [HR], 1.51). Pain intensity and pain interference were not statistically significant. Nonchronic pressure ulcer was related to 67% higher mortality risk (HR, 1.67), and chronic pressure ulcer was related to 122% higher risk (HR, 2.22). Other health indicators also increased the risk of mortality from 43% to 73%, including hospitalization (HR, 1.54), depression (HR, 1.43), and amputation (HR, 1.73).ConclusionsPrescription pain medication use appears to have a direct association with mortality, beyond that associated with other characteristics, and should become a strong focus of prevention efforts.Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

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