• Mustafa Kerem, Zafer Ferahkose, Utku Tonguc Yilmaz, Hatice Pasaoglu, Ebru Ofluoglu, Abdulkadir Bedirli, Bulent Salman, Tevfik Tolga Sahin, and Murat Akin.
• Department of General Surgery, Faculty of Medicine, Gazi University, Besevler 06510, Ankara, Turkey. keremm1@yahoo.com.
• World J Gastroentero. 2008 Jun 21; 14 (23): 3633-41.

AimTo investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia.MethodsResistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor (IGF-I), were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones, body mass index (BMI) loss ratio, age, gender, and Glasgow Prognostic Score (GPS) were investigated.ResultsCachexia patients had higher tumor stage and GPS when compared with non-cachexia patients (P < 0.05). Ghrelin, resistin, leptin, adiponectin and IGF-I, showed a significant correlation with BMI loss ratio and GPS (P < 0.05). A strong correlation was seen between GPS and BMI loss (R = -0.570, P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin, resistin, leptin and IGF-I (P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted.ConclusionThese results showed that serum ghrelin, leptin, adiponectin, and IGF-I play important roles in cachexia-related gastric cancers. No relationship was found between resistin and cancer cachexia. Also, because of the correlation between these parameters and GPS, these parameters might be used as a predictor factor.

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