• Thoracic surgery clinics · Nov 2013

    Review

    Chemoradiation for esophageal cancer.

    • Mariela A Blum, Takashi Taketa, Kazuki Sudo, Roopma Wadhwa, Heath D Skinner, and Jaffer A Ajani.
    • Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
    • Thorac Surg Clin. 2013 Nov 1; 23 (4): 551-8.

    AbstractEsophageal cancer management is based on baseline clinical stage, location of the tumor, and associated comorbid conditions. In patients with localized esophageal cancer (LEC) with technically resectable tumors and who are medically fit for surgery, the current recommendation is trimodality therapy (chemoradiation followed by surgery). Bimodality therapy (definitive chemoradiation) is reserved for patients with cervical esophageal tumors, technically unresectable tumors, for patients who cannot be recommended surgery due to medical comorbidities, or those who decline surgery. Prospective data from 2 studies suggest that definitive chemoradiation may be sufficient for LEC with squamous cell histology; a definite answer, however, is unclear. Copyright © 2013 Elsevier Inc. All rights reserved.

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