• Bulletin du cancer · Feb 2019

    Review

    Immunotherapy and metastatic colorectal cancers with microsatellite instability or mismatch repair deficiency.

    • Romain Cohen, Anna Pellat, Hélène Boussion, Magali Svrcek, Daniel Lopez-Trabada, Isabelle Trouilloud, Pauline Afchain, and Thierry André.
    • AP-HP, Sorbonne université, hôpital Saint-Antoine, department of medical oncology, 75012 Paris, France. Electronic address: romain.cohen@aphp.fr.
    • Bull Cancer. 2019 Feb 1; 106 (2): 137-142.

    AbstractMicrosatellite instability (MSI) is a molecular indicator of defective DNA mismatch repair (dMMR) and is observed in approximately 5% of metastatic colorectal cancers (mCRC). MSI is a major predictive biomarker for the efficacy of immune checkpoint inhibitors (ICKi) amongst mCRC patients. After summarizing the literature about the efficacy of conventional cytotoxic regimens, we will highlight studies that have demonstrated the clinical activity of ICKi for patients with chemoresistant MSI/dMMR mCRC. Then we will focus on ongoing clinical trials and emerging challenges for the treatment of patients with MSI/dMMR mCRC.Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

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