• Sci China Life Sci · Apr 2016

    Review

    Adoptive therapy with CAR redirected T cells for hematological malignancies.

    • Shiqi Li, Zhi Yang, Junjie Shen, Juanjuan Shan, and Cheng Qian.
    • Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
    • Sci China Life Sci. 2016 Apr 1; 59 (4): 370-8.

    AbstractThe survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor (CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.

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