• Gan To Kagaku Ryoho · Nov 2011

    [Chemotherapy-induced peripheral neuropathy].

    • Emi Noguchi and Yoshiharu Maeda.
    • Dept. of Chemotherapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Tokyo, Japan.
    • Gan To Kagaku Ryoho. 2011 Nov 1; 38 (11): 1773-6.

    AbstractChemotherapy-induced peripheral neuropathy(CIPN)is one of chemotherapy's common and disabling adverse effects. It may be caused by many chemotherapeutic agents including the taxanes(paclitaxel, docetaxel), the vinca alkaloids(vincristine, vinorelbine, vinblastine), the platinum analogues(cisplatin, carboplatin, oxaliplatin), bortezomib and thalidomide, among others. Once the symptoms have developed, they may lead to compromising patients' quality of life(QOL). For medical oncologists, the management of CIPN remains an important challenge. At the present time, no agent has shown enough solid beneficial evidence to be recommended for the treatment or/prophylaxis of CIPN. The standard of care for CIPN includes awareness and early detection of neuropathy, and dose reduction and/or discontinuation of the problematic agents.

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