• J. Peripher. Nerv. Syst. · Dec 2009

    Neuropathic pain is associated with increased nodal persistent Na(+) currents in human diabetic neuropathy.

    • Sonoko Misawa, Kenichi Sakurai, Kazumoto Shibuya, Sagiri Isose, Kazuaki Kanai, Jun Ogino, Ko Ishikawa, and Satoshi Kuwabara.
    • Department of Neurology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan. sonoko.m@mb.infoweb.ne.jp
    • J. Peripher. Nerv. Syst. 2009 Dec 1; 14 (4): 279-84.

    AbstractPeripheral nerve injury alters function and expression of voltage gated Na(+) channels on the axolemma, leading to ectopic firing and neuropathic pain/paresthesia. Hyperglycemia also affects nodal Na(+) currents, presumably due to activation of polyol pathway and impaired Na(+)-K(+) pump. We investigated changes in nodal Na(+) currents in peripheral sensory axons and their relation with pain in human diabetic neuropathy. Latent addition using computerized threshold tracking was used to estimate nodal persistent Na(+) currents in radial sensory axons of 81 diabetic patients. Of these, 36 (44%) had chronic neuropathic pain and severe paresthesia. Compared to patients without pain, those with pain had greater nodal Na(+) currents (p = 0.001), smaller amplitudes of sensory nerve action potentials (SNAP) (p = 0.0003), and lower hemoglobin A1c levels (p = 0.006). Higher axonal Na(+) conductance was associated with smaller SNAP amplitudes (p = 0.03) and lower hemoglobin A1c levels (p = 0.008). These results suggest that development of neuropathic pain depends on axonal hyperexcitability due to increased nodal Na(+) currents associated with structural changes, but the currents could also be affected by the state of glycemic control. Our findings support the view that altered Na(+) channels could be responsible for neuropathic pain/paresthesia in diabetic neuropathy.

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