• Brain Nerve · Nov 2010

    Review

    [Gait disturbance and deep brain stimulation].

    • Wataru Sako.
    • Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University, Graduate School of Medical Sciences, Tokushima, Japan.
    • Brain Nerve. 2010 Nov 1; 62 (11): 1221-5.

    AbstractGait disturbance, one of the axial symptoms, is caused by various disorders, including basal ganglia disease. Deep brain stimulation (DBS) has widened the spectrum of therapeutic options for patients with gait disturbance due to Parkinson disease and dystonia. In gait disturbance caused by basal ganglia disease, the main targets of DBS are the subthalamic nucleus (STN) and globus pallidus internus (GPi). STN DBS is more than GPi DBS effective for treating levodopa-responsive parkinsonian symptoms, including gait disturbance. GPi DBS is effective for the treatment of primary segmental or generalized dystonia. The pedunculopontine tegmental nucleus (PPN), which is involved in locomotion, is one of the new targets for treating gait disturbance in Parkinson disease. We review DBS in the treatment of gait disturbance due to Parkinson disease and dystonia.

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