• Jessica Bomyea, Laura A Flashman, Ross Zafonte, Norberto Andaluz, Raul Coimbra, Mark S George, Gerald A Grant, Christine E Marx, Thomas W McAllister, Lori Shutter, Ariel J Lang, and Murray B Stein.
• VA San Diego Healthcare System Center of Excellence for Stress and Mental Health, La Jolla, CA, USA; University of California, San Diego Department of Psychiatry, La Jolla, CA, USA; University of Pittsburgh, Department of Critical Care Medicine, Neurology, and Neurosurgery, Pittsburgh, PA, USA. Electronic address: jbomyea@ucsd.edu.
• Psychiatry Res. 2019 Feb 1; 272: 531-539.

AbstractMild traumatic brain injury (mTBI) is a common occurrence, and may impact distal outcomes in a subgroup of individuals. Improved characterization of health outcomes and identification of factors associated with poor outcomes is needed to better understand the impact of mTBI, particularly in those with co-occurring posttraumatic stress disorder (PTSD). Participants in a data repository of the Injury and Traumatic Stress (INTRuST) Clinical Consortium (n = 625) completed functional disability [FD] and health-related quality of life [HRQOL] questionnaires, and a subset completed a neuropsychological assessment. FD and HRQOL were compared among participants with probable mTBI (mTBI), probable mTBI with PTSD (mTBI/PTSD), and health comparison participants (HC). Associations between symptoms, neuropsychological performance, and health outcomes were examined in those with probable mTBI with and without PTSD (n = 316). Individuals in the mTBI/PTSD group endorsed poorer health outcomes than those in the mTBI group, who endorsed poorer outcomes than those in the HC group. Individuals in either mTBI group performed worse than those in the HC on verbal learning and memory and psychomotor speed. Health outcomes were correlated with mental health and postconcussive symptoms, as well as neuropsychological variables. mTBI may adversely impact self-reported health, with the greatest effect observed in individuals with co-occurring mTBI/PTSD.Copyright © 2018. Published by Elsevier B.V.

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