• Med. Clin. North Am. · Jul 2015

    Review

    New oral anticoagulants: their role in stroke prevention in high-risk patients with atrial fibrillation.

    • Sunita J Ferns and Gerald V Naccarelli.
    • Department of Pediatrics, University of North Carolina, College of Medicine, 101 Manning Drive, Chapel Hill, NC 27599, USA.
    • Med. Clin. North Am. 2015 Jul 1; 99 (4): 759-80.

    AbstractBased on efficacy, safety, and ease of use, novel oral anticoagulants will likely replace VKAs for many if not most patients with atrial fibrillation. Novel anticoagulants have a lower rate of intracranial hemorrhage compared with vitamin K antagonists. The incidence of other life-threatening bleeds is similar if not lower. Dose adjustments need to be made based on renal function and advanced age. There is at present a need for an antidote for these new drugs. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

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