• Andrew McNeice, Imad J Nadra, Simon D Robinson, Eric Fretz, Lillian Ding, Anthony Fung, Eve Aymong, Albert W Chan, Steven Hodge, John Webb, Tej Sheth, Sanjit S Jolly, Shamir R Mehta, Della Siega Anthony A Victoria Heart Institute Foundation, Victoria, BC, Canada. Royal Jubilee Hospital,, David A Wood, M Bilal Iqbal, and British Columbia Cardiac Registry Investigators.
• Victoria Heart Institute Foundation, Victoria, BC, Canada.
• Catheter Cardiovasc Interv. 2018 Nov 1; 92 (5): E356-E367.

BackgroundIn patients with acute myocardial infarction (AMI) and cardiogenic shock (CS), percutaneous coronary intervention (PCI) of the culprit vessel is associated with improved outcomes. A large majority of these patients have multivessel disease (MVD). Whether or not PCI of non-culprit disease in the acute setting improves outcomes continues to be debated. We evaluated the prognostic impact of revascularization strategy for patients presenting with AMI and CS.MethodsWe compared culprit vessel intervention (CVI) versus multivessel intervention in 649 patients with AMI, CS, and MVD enrolled in the British Columbia Cardiac Registry. We evaluated mortality at 30 days and 1 year.ResultsCVI was associated with lower mortality at 30 days (23.7% vs. 34.5%, P = 0.004) and 1 year (32.6% vs. 44.3%, P = 0.003). CVI was an independent predictor for survival at 30 days (HR = 0.63, 95% CI: 0.45-0.88, P = 0.009) and 1 year (HR = 0.72, 95% CI: 0.54-0.96, P = 0.027). These findings were confirmed in propensity-matched cohorts. Subgroup analyses indicated that CVI was associated with lower mortality in patients aged <80 years; non-diabetics; and those presenting with ST-elevation MI. When analyzing non-culprit anatomy, PCI of non-culprit LAD disease was associated with higher 1-year mortality (HR = 1.51, 95% CI: 1.13-2.01, P = 0.006), primarily with non-culprit proximal LAD disease (HR = 1.82, 95% CI: 1.20-2.76, P = 0.005). However, PCI of non-culprit non-proximal LAD, LCx, and RCA disease was not associated with mortality.ConclusionsIn patients with AMI and CS, a strategy of CVI appears to be associated with lower mortality. These findings are consistent with recently published randomized-controlled trial data.© 2018 Wiley Periodicals, Inc.

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