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J. Am. Acad. Dermatol. · Feb 1993
Review Case ReportsExtensive cutaneous hyperpigmentation caused by minocycline.
- M Pepine, F P Flowers, and F A Ramos-Caro.
- Department of Medicine, University of Florida College of Medicine, Gainesville.
- J. Am. Acad. Dermatol. 1993 Feb 1; 28 (2 Pt 2): 292-5.
AbstractA 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2 1/2 years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.
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