• Sven-Petter Haugvik, Marangos Irina Pavlik IP, Bård Ingvald Røsok, Ewa Pomianowska, Ivar Prydz Gladhaug, Oystein Mathisen, and Bjørn Edwin.
• Department of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway. svhaug@ous-hf.no
• World J Surg. 2013 Mar 1; 37 (3): 582-90.

BackgroundAs most pancreatic neuroendocrine tumors (PNET) are relatively small and solitary, they may be considered well suited for removal by a minimally invasive approach. There are few large series that describe laparoscopic surgery for PNET. The primary aim of this study was to describe the feasibility, outcome, and histopathology associated with laparoscopic pancreatic surgery (LS) of PNET in a large series.MethodsAll patients with PNET who underwent LS at a single hospital from March 1997 to April 2011 were included retrospectively in the study.ResultsA total of 72 patients with PNET underwent 75 laparoscopic procedures, out of which 65 were laparoscopic resections or enucleations. The median operative time of all patients who underwent resections or enucleations was 175 (60-520) min, the median blood loss was 300 (5-2700) ml, and the median length of hospital stay was 7 (2-27) days. The overall morbidity rate was 42%, with a surgical morbidity rate of 21% and postoperative pancreatic fistula (POPF) formation in 21%. Laparoscopic enucleations were associated with a higher rate of POPF than were laparoscopic resections. Five-year disease-specific survival rate was 90%. The T stage, R stage, and a Ki-67 cutoff value of 5% significantly predicted 5-year survival.ConclusionLS of PNET is feasible with acceptable morbidity and a good overall disease-specific long-term prognosis.

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