• Surg Obes Relat Dis · Mar 2010

    Comparative Study Controlled Clinical Trial

    Prospective controlled study of effect of laparoscopic sleeve gastrectomy on small bowel transit time and gastric emptying half-time in morbidly obese patients with type 2 diabetes mellitus.

    • Shashank Shah, Poonam Shah, Jayashree Todkar, Michel Gagner, S Sonar, and S Solav.
    • Department of Surgery, Ruby Hall Clinic, Pune, India. drshashankshah@ediffmail.com
    • Surg Obes Relat Dis. 2010 Mar 4; 6 (2): 152-7.

    BackgroundPublished data on sleeve gastrectomy (SG) have indicated better remission of type 2 diabetes mellitus (T2DM) and improvement in satiety compared with other restrictive procedures. Mechanisms in addition to rapid, extensive weight loss are responsible for the restoration of the euglycemic state. To prospectively evaluate the role of laparoscopic SG on gastric emptying half-time and small bowel transit time (SBTT) and effect of these on weight loss, satiety, and improvement in T2DM.MethodsA total of 67 subjects were studied. Of these 67 subjects, 24 were lean controls (body mass index 22.2 +/- 2.84 kg/m(2)), 20 were severely and morbidly obese patients with T2DM who had not undergone SG (body mass index 37.73 +/- 5.35 kg/m(2)), and 23 were severely and morbidly obese patients with T2DM after SG (body mass index 40.71 +/- 6.59 kg/m(2)). All 67 patients were evaluated for gastric emptying half-time and SBTT using scintigraphic imaging. Imaging was performed every 15 minutes up to the ileocecal region. The Three-Factor Eating Questionnaire was administered simultaneously. Fasting blood sugar, postprandial blood sugar, and glycated hemoglobin were assessed. Nonparametric analysis of variance and the Mann-Whitney U test were applied.ResultsThe mean SBTT was significantly lower (P <.05) in the post-SG group (199 +/- 65.7 minutes) than in the non-SG group (281.5 +/- 46.2 minutes) or control group (298.1 +/- 9.2 minutes). The gastric emptying half-time values were also significantly shorter (P <.05) in the post-SG (52.8 +/- 13.5 minutes) than in the non-SG (73.7 +/- 29.0 minutes) and control (72.8 +/- 29.6 minutes) groups. The glycated hemoglobin, fasting blood sugar, and postprandial sugar were all significantly lower after SG. The Three-Factor Eating Questionnaire findings revealed significantly earlier satiety (29.0 +/- 7.2) for the post-SG patients (P <.05) compared with the non-SG (45.8 +/- 9.0) and control (37.9 +/- 6.2) subjects.ConclusionA decreased gastric emptying half-time and SBTT after SG can possibly contribute to better glucose homeostasis in patients with T2DM.Copyright 2010 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…