• Toshitaka Hoppo, Veronica Jarido, Arjun Pennathur, Matthew Morrell, Maria Crespo, Norihisa Shigemura, Christian Bermudez, John G Hunter, Yoshiya Toyoda, Joseph Pilewski, James D Luketich, and Blair A Jobe.
• Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15232, USA.
• Arch Surg. 2011 Sep 1; 146 (9): 1041-7.

BackgroundGastroesophageal reflux disease (GERD) is common in patients with end-stage lung disease (ESLD). GERD may cause obliterative bronchiolitis after lung transplantation (LTx), represented by a decline in forced expiratory volume in 1 second (FEV(1)).ObjectivesTo identify the patterns of reflux in patients with ESLD and to determine whether antireflux surgery (ARS) positively impacts lung function.DesignRetrospective review of prospectively collected data.SettingTertiary care university hospital.PatientsForty-three patients with ESLD and documented GERD (pre-LTx, 19; post-LTx, 24).InterventionsAntireflux surgery.Main Outcome MeasuresReflux patterns including laryngopharyngeal reflux as measured by esophageal impedance, and FEV(1), and episodes of pneumonia and acute rejection before and after ARS.ResultsBefore ARS, 19 of 43 patients (44%) were minimally symptomatic or asymptomatic. Laryngopharyngeal reflux events, which occurred primarily in the upright position, were common in post-LTx (56%) and pre-LTx (31%) patients. At 1 year after ARS, FEV(1) significantly improved in 91% of the post-LTx patients (P < .01) and 85% of the pre-LTx patients (P = .02). Of patients with pre-ARS declining FEV(1), 92% of post-LTx and 88% of pre-LTx patients had a reversal of this trend. Episodes of pneumonia and acute rejection were significantly reduced in post-LTx patients (P = .03) or stablilized in pre-LTx patients (P = .09).ConclusionsThere should be a low threshold for performing objective esophageal testing including esophageal impedance because GERD may be occult and ARS may improve or prolong allograft and native lung function.

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