• Hum Vaccin Immunother · Jul 2016

    Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils.

    • Kim Thomsen, Lars Christophersen, Peter Østrup Jensen, Thomas Bjarnsholt, Claus Moser, and Niels Høiby.
    • a Department of Clinical Microbiology , Rigshospitalet, Copenhagen University Hospital , Copenhagen , Denmark.
    • Hum Vaccin Immunother. 2016 Jul 2; 12 (7): 1690-9.

    AbstractModeration of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

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