• Yu Miao, Zhou Yu-Jie, Wang Zhi-Jian, Shi Dong-Mei, Liu Yu-Yang, Zhao Ying-Xin, Gao Fei, Yang Shi-Wei, and Jia De-An.
• Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing, China.
• Catheter Cardiovasc Interv. 2012 Sep 1; 80 (3): 361-7.

BackgroundChronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug-eluting stent (DES) implantation are limited.ObjectivesThis study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function.MethodsWe consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1-year definite or probable ST.ResultsFour hundred and forty-five participants (15.5%) had CKD before procedure. The incidence of 1-year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1-year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165-0.951, P = 0.038).ConclusionCKD is significantly associated with increased incidence of 1-year definite or probable ST in patients undergoing PCI with DES.Copyright © 2012 Wiley Periodicals, Inc.

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