• Swiss medical weekly · Jul 1989

    Case Reports

    [Monoclonal gammopathies of undetermined significance called "MGUS"].

    • F Clément.
    • Division d'hématologie, Centre hospitalier universitaire vaudois, Lausanne.
    • Swiss Med Wkly. 1989 Jul 11; 119 (27-28): 970-8.

    AbstractWhile the discovery of a monoclonal gammopathy in the blood of a patient sometimes leads to the diagnosis of multiple myeloma, immunocytoma or other B-cell lymphoproliferative syndromes, "secondary" monoclonal dysproteinemia is seldom considered. In most cases "monoclonal gammopathy of undetermined significance" (MGUS) is diagnosed. After ten years about 25% of these cases evolve to true multiple myeloma or Waldenström's disease. Other MGUS usually remain asymptomatic, though sometimes a complication such as amyloidosis or cryoglobulinemia may occur as a result of the "perverse" effect of the monoclonal protein. Some cases are described.

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