• In vivo · Jun 2020

    Review

    Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.

    • Karel Smetana and Jan Brábek.
    • Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic jan.brabek@natur.cuni.cz karel.smetana@lf1.cuni.cz.
    • In Vivo. 2020 Jun 1; 34 (3 Suppl): 1589-1592.

    AbstractCOVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy.Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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