• J Craniofac Surg · Sep 2013

    Randomized Controlled Trial Comparative Study

    Study comparing midazolam and nitrous oxide in dental anxiety control.

    • Darklilson Pereira-Santos, Marcus Antônio Brêda-Júnior, Emanuela Prado Ferraz, Grasiele Edilaine Crippa, Fabíola Singaretti de Oliveira, and Valdemar Mallet da Rocha-Barros.
    • From the Oral and Maxillofacial Surgery and Periodontology Department, Ribeirão Preto Dental School, São Paulo University, São Paulo, Brazil.
    • J Craniofac Surg. 2013 Sep 1; 24 (5): 1636-9.

    AbstractThe purpose of this study is to comparatively assess the effect of midazolam and nitrous oxide associated with oxygen, in lower third molar extractions, on the change in the anxiety level of patients by salivary cortisol dosage. Twenty-eight male patients underwent lower third molar extraction under sedation with midazolam and nitrous oxide. Objective (salivary cortisol dosage) and subjective (Corah Dental Anxiety Scale) data have been obtained. By salivary cortisol, 40 minutes after midazolam administration, there has been a statistically significant difference compared with the mean baseline value. Midazolam was the most effective sedation method for reducing salivary cortisol level.

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