• Blood purification · Jan 2013

    Review

    Genomics and biological activity of neutrophil gelatinase-associated lipocalin in several clinical settings.

    • Grazia Maria Virzì, Anna Clementi, Massimo de Cal, Dinna N Cruz, and Claudio Ronco.
    • Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.
    • Blood Purif. 2013 Jan 1; 35 (1-3): 139-43.

    AbstractRecent literature has shown that neutrophil gelatinase-associated lipocalin (NGAL) is one of the most interesting and promising biomarkers in case of acute kidney injury. However, several studies indicated that this protein may be applied beyond the boundaries of renal pathophysiology and may be used in other pathophysiological settings since it is also expressed in neutrophils, and respiratory, bowel and prostate epithelia. In this review, we report NGAL genomics and biology and its possible use in several clinical settings. In particular, we review the genomic organization of the NGAL gene, the lipocalin family structure, the interaction between NGAL and ligands, and the induction and expression of NGAL in different conditions.Copyright © 2013 S. Karger AG, Basel.

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